Medication guide

Lorazepam (Ativan / Wypax)

What is lorazepam?

Lorazepam is known as Ativan in the United States and the UK, and Wypax in Japan (ワイパックス on Japanese packaging); it's all the same medicine. It's an anti-anxiety medicine in the benzodiazepine group: it calms an overactive nervous system, easing anxiety and tension, and it works fairly quickly. It's used for short-term relief, often just when needed.

How is it different from other anxiety medicines?

Fast: it calms within an hour or so, not the weeks an antidepressant needs
Simple in the body: broken down without involving the liver's main drug pathways, so it has few interactions and is often chosen for older adults or people on many medicines
Works as needed: it can be taken only when anxiety spikes, rather than every day
A useful bridge: often prescribed alongside a daily antidepressant while that slower medicine takes hold

What is it used for in Japan?

In Japan, lorazepam is approved for the symptoms that come with neurosis and stress-related physical (psychosomatic) conditions:

Anxiety and tension
Low mood
The physical symptoms of those stress-related conditions

How does it help?

It gently quietens the nervous system, so anxiety and tension ease off, usually within a fairly short time of taking it. It works best as short-term support alongside treatment that fixes the underlying problem, not as something taken every day for years.

What should I tell my doctor before starting?

A few situations rule it out entirely; your doctor will choose something else if any of these apply:

Acute narrow-angle glaucoma
Myasthenia gravis (a muscle-weakness condition)

And tell your doctor first if any of these apply; these usually just need adjustments or a closer eye:

A previous bad reaction to lorazepam
Serious breathing problems, or breathing problems during sleep
Other sedating medicines, or regular alcohol use
A history of alcohol or substance dependence
Being older: a lower dose is usual, as unsteadiness and falls are more likely
Pregnant, planning to be, or breastfeeding (see the section below)

How do I take it?

Your doctor will set the pattern: either only when needed, or on a regular short-term schedule.

It works within about an hour, so there's no need to "wait for it to build up"
Don't raise the dose or add extra tablets on your own, even on a bad day; if it feels like it's not enough, that's a conversation, not a second tablet
If you're on a regular schedule and miss a dose, just skip it if the next one is close. Never double up
Avoid alcohol; it stacks with the drowsiness

What side effects should I expect?

Most are mild. Not everyone gets them.

Drowsiness: the most common
Unsteadiness, dizziness, or light-headedness: take care on your feet
Tiredness or a feeling of weakness

If anything is bothering you, tell your doctor; there's often a way to adjust.

Finally, one thing that is rare, and avoidable:

Combined with alcohol or other sedatives, the drowsiness can run deeper than expected; if you ever feel unusually heavily sedated or your breathing feels slowed, call us the same day. Taken as prescribed, without alcohol, this is very unlikely

Will I become dependent? How do I stop safely?

Honestly: it can be habit-forming with regular use, which is exactly why it's used short term, at the lowest helpful dose, with a clear plan. The body gets used to benzodiazepines, the same dose can gradually do less, and stopping suddenly after regular use can cause withdrawal: rebound anxiety, sleeplessness, and, in some cases, seizures. So never stop suddenly on your own; your doctor lowers it gradually, and as-needed use (rather than daily) keeps the risk low. Used as planned, it's a helpful and safe bridge; the goal is always that the longer-term treatment takes over.

Can I bring it into Japan?

Yes, within limits, because it's a controlled medicine here. Lorazepam is a scheduled (psychotropic) medicine in Japan: a personal supply of roughly up to a month travels with you without advance permission (original packaging, prescription in hand), larger amounts need an advance import certificate, and mailing it to Japan is prohibited. Japanese rules also don't allow it to be prescribed at a first online visit, so plan an in-person start.

Can I drive while taking it?

No; avoid driving while you're taking it. Like other benzodiazepines, lorazepam slows reaction time and attention, and the Japanese label instructs that patients on it should not drive or operate dangerous machinery. This applies while the medicine is in your system, including the day after an evening dose if you feel dulled.

What about pregnancy and breastfeeding?

Generally avoided in both; tell your doctor early and we'll find the safest plan together. Benzodiazepines are not an automatic emergency in pregnancy, but they're not the preferred tools either, and use around delivery and during breastfeeding is avoided where possible. If you're on lorazepam and planning a pregnancy, don't stop suddenly; the plan is a gradual, supported change. Our guides to medication in pregnancy and medication while breastfeeding cover the wider picture.